Do you risk all that you have when starting a new business?
However, you may run into transactions where the other side would want you to provide a personal guaranty. Landlords and banks are often queasy about working with brand-new companies. Therefore, they will want you to "guarantee" that you personally will make good on the debt if the company goes out of business. In those limited situations, your personal assets would be at risk.
Another way to ensure that you don’t "risk the farm" is to put together a careful business plan and have sufficient funds set aside to get started, so you don’t have to ask others to loan you money.