However, if you do require a license -- just as attorneys, social workers and massage therapists do -- it makes no difference if you're operating from home or not.
You'll need the licenses as a result of your profession. Check with your local secretary of state to determine the licensing requirements of your profession in your state.
Nina L. Kaufman, Esq. is an award-winning New York City attorney, edutainer and author. Under her Ask The Business Lawyer brand, she reaches thousands of entrepreneurs and small business owners with her legal services, professional speaking, information products, and LexAppeal weekly ezine. She also writes the Making It Legal blog.