Leaving your home office for an out-of-town destination involves preparation and planning, but it shouldn't include worrying--at least not about how to keep in touch with your office while you're on the road.
First, before leaving, let your most important contacts know you'll be out of town and when you'll be back. Also be sure to leave a message on your answering machine specifically stating how long you'll be gone, when you'll be back and, most important, how often you'll be checking your messages. Customers and clients want to feel secure that you'll get back to them as soon as possible. For instance, let your clients know you'll be checking messages each day at 1 p.m., and then return calls the same day to anyone who needs to speak with you immediately.
Finally, take advantage of e-mail. It's an excellent alternative to traditional forms of communication--and less expensive. Check with your hotel to see what kinds of business services (free faxing, e-mail service, etc.) they offer guests, and don't be timid about using them. Staying in contact with your clients while you're on the road will not only keep them happy, but it will make your life less hectic when you return.