ARRAY BIOPHARMA REPORTS 3RD QTR NET LOSS OF 14 MILLION.

Array BioPharma Inc.,(NASDAQ: ARRY), Boulder, Colo., has reported financial results for the third quarter of fiscal 2007. Array reported revenue of $10.4 million for the third quarter of fiscal 2007, compared to revenue of $11.7 million for the same period in fiscal 2006. Collaboration revenue decreased as a result of shifting resources to advance and expand Array's internal proprietary drug discovery programs. Revenue from license fees and milestone payments increased due to achieving milestones that trigger payments from AstraZeneca PLC and InterMune, Inc. Array invested $15.7 million in proprietary research and development for the quarter in connection with advancing its eight wholly owned development programs as well as its portfolio of discovery programs.

This compares to $7.7 million during the same quarter last year. Array reported a net loss of $14.1 million, or ($0.35) per share, for the third quarter, compared to a net loss of $9.2 million, or ($0.24) per share, for the same quarter in fiscal 2006. Array ended the third quarter of fiscal 2007 with $73.9 million in cash, cash equivalents and marketable securities. "Array has a deep development pipeline which now includes five oncology programs and three programs for treating inflammatory disease," said Robert E. Conway, CEO, Array BioPharma. "During the remainder of calendar 2007, we anticipate having catalysts on six wholly-owned Array drugs, including advancing two drugs into Phase 2 clinical trials and filing two more INDs."

Third Quarter and Subsequent Accomplishments:

Advancing Proprietary Research Programs

ARRY-886 (AZD6244), a novel MEK inhibitor, is being developed by AstraZeneca and is in Phase 2 clinical assessment in metastatic melanoma, colorectal, pancreatic and non-small cell lung cancers. ARRY-704 (AZD8330), a novel MEK inhibitor, entered a Phase 1 clinical trial initiated by AstraZeneca in cancer patients, triggering a $2 million milestone payment to Array. Array's co-development and commercialization partnership with AstraZeneca for the oncology portion of its MEK portfolio, including its lead compound, ARRY-886, included research and development of additional clinical candidates, which resulted in the selection of ARRY-704 in December 2005.

Advanced ARRY-543, an oral, selective, reversible, small molecule tyrosine kinase inhibitor of both ErbB-2 and EGFR for cancer, in a Phase 1 clinical trial. Array reported positive Phase 1 interim results in December 2006: the compound demonstrated consistent drug exposure and four patients had stable disease at doses that were well tolerated. Continued a Phase 1 clinical trial in healthy volunteers for Array's first-in-class MEK inhibitor for inflammatory disease, ARRY-162. There have been no serious adverse events through 14 days of continuous dosing and cytokine production was significantly inhibited after ex-vivo stimulation of clinical samples. Results of this trial will be presented at the European League Against Rheumatism (EULAR) Congress in June 2007.

Continued a Phase 1b combination trial with ARRY-162 and methotrexate in stable rheumatoid arthritis patients, which will evaluate safety, tolerability, pharmacokinetics, biomarkers and initial signs of efficacy.

Completed a Phase 1a single ascending dose escalation study in healthy volunteers for ARRY-797, a selective, orally active p38 inhibitor for inflammation, which evaluated safety, exposure and inhibition of mechanism-related biomarkers. Results of this trial will be presented at the European League Against Rheumatism (EULAR) Congress in June 2007. Filed an Investigational New Drug (IND) application for ARRY-797 with the U.S. Food & Drug Administration (FDA) and is now able to proceed with a Phase 1 clinical trial in cancer patients. ARRY-797 has shown good efficacy and a low side effect profile in preclinical models of certain cytokine-driven cancers.

Initiated enrollment of cancer patients to participate in a Phase 1 clinical trial for ARRY-520, a small molecule Kinesin Spindle Protein (KSP) inhibitor. In vivo, ARRY-520 caused marked tumor regression in preclinical models of human solid tumors and human leukemias, often leading to durable responses.

Finishing regulated safety assessment testing for ARRY-380, an oral, selective ErbB-2 inhibitor for cancer, and preparing an IND application to submit to the FDA.

Identified and advanced into regulated safety assessment testing a new compound, ARRY-614, a p38 / Tie-2 inhibitor for inflammation and cancer. This mechanism simultaneously targets both cytokine growth-driven and angiogenesis-driven mechanisms in cancer. The compound has shown to block angiogenesis, inhibit inflammation and antagonize tumor growth, while also demonstrating a low side effect profile in preclinical models of human cancer and arthritis.

Partnered Research

Entered into a license agreement with VentiRx Pharmaceuticals Inc., a privately held biopharmaceutical company, granting VentiRx exclusive worldwide rights to Array's Toll-like receptor (TLR) program. The program contains a number of development candidates targeting TLRs to activate innate immunity. VentiRx expects to develop its first two candidates in oncology and allergy. Financial terms of the agreement were not disclosed, but Array received an equity stake in VentiRx as well as an upfront payment, and will receive potential milestone payments and royalties on product sales. Array retains the option to acquire a 50% ownership position in all VentiRx clinical oncology products developed under this agreement. Received a $500,000 milestone payment from InterMune, Inc. for ITMN-191, an oral hepatitis C virus protease inhibitor, being dosed in patients in a Phase 1a clinical trial.

Enhancing Leadership

Appointed Neil Spector, M.D., to Array's Scientific Advisory Board. Dr. Spector will help Array in the development of its cancer portfolio. Dr. Spector, with 20 years of oncology experience, recently joined Duke University Medical Center's cancer drug development team as the new Director of Translational Research in Oncology. He also serves as Co-Director of the Experimental Therapeutics Program in the cancer center. Prior to joining Duke, Dr. Spector served as Director of GlaxoSmithKline's Exploratory Medical Sciences in Oncology, where he successfully developed two important cancer drugs, Tykerb (lapatinib) and Nelarabine (ara-G analog), from the bench to the clinic and then guided them through FDA approval.

Array reported revenue of $29.0 million for the nine-month period ended March 31, 2007, compared to revenue of $34.9 million for the same period in fiscal 2006. Net loss for the nine months ended March 31, 2007, was $38.2 million, or ($0.97) per share, compared to a net loss of $27.6 million, or ($0.71) per share, reported in the same period in fiscal 2006.

About Array BioPharma

Array BioPharma Inc. is a biopharmaceutical company focused on the discovery, development and commercialization of targeted small molecule drugs to treat life threatening and debilitating diseases. Our proprietary drug development pipeline is focused on the treatment of cancer and inflammatory disease and includes clinical candidates that are designed to regulate therapeutically important targets. In addition, leading pharmaceutical and biotechnology companies collaborate with Array to discover and develop drug candidates across a broad range of therapeutic areas.

For more information, vist http://www.arraybiopharma.com or 303/386-1193.