Patch-clamp methods and protocols.

9781588296986

Patch-clamp methods and protocols.

Ed. by Peter Molnar and James J. Hickman.

Humana Press Inc.

2007

321 pages

$99.50

Hardcover

Methods in molecular biology; 403

QP341

This electrophysiology technique is the primary standard for studying interactions in pharmacology, physiology and biophysics, and this gives techniques for each field. Topics include whole-cell patch-clamp methods, fast and voltage-dependent receptor blockers, methods of evaluating positive allosteric modulators, automated voltage-clamp techniques, automated patch clamping based on glass electrodes, automated electrophysiology, infrared-guided laser simulation, determinants of neuronal diversity, scanning probe microscopy and patch-clamp investigations of mechanosensitive ion channels, synaptic connectivity in engineered neuronal networks, modeling of action potentials, silicon-clamp techniques on skeletal muscle fibers, determination of channel properties at the unitary level, electrophysiological properties of embryonic stem cells, hybrid neuronal network studies under dynamic clamp, cardiac channelopathologies studied with the dynamic action potential-clamp techniques, principles of single-channel kinetic analysis, measurement of ion selectivity of pore-forming peptides and ion channels and estimation of quantal parameters with multiple-probability fluctuation analysis. Requires basic electrophysiological training and experience.

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