9783527318216
Antitargets; prediction and prevention of drug side effects.
Ed. by Roy J. Vaz and Thomas Klabunde.
Wiley-VCH
2008
480 pages
$190.00
Hardcover
Methods and principles in medicinal chemistry; v.38
RM302
Much pharmaceutical research has gone right, but much has also been
thwarted by adverse reactions to small-molecule drugs. This collection
of 19 articles, which includes several case studies, focuses on the
practical by describing leading-edge methods of studying, predicting and
preventing such side effects. Contributors cover general issues, such as
why new chemical entities fail, and how to use broad biological
profiling, ion channels and G-protein coupled receptors to mediate side
effects. They also cover a broad range of drug-to-drug interactions,
with several articles covering the prevention of cytochrome P450
inhibition and induction along with drug transporters. The case studies
of drug optimization against antitargets include the development of
sitagliptin, the discovery of a way to improve an anti-anxiety
medication, and new strategy and tactics for hERG optimization. This
provides key knowledge for medicinal and pharmaceutical chemists,
toxicologists, molecular biologists and pharmacists as well as for drug
developers.
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