San Diego public stocks.

Index Watch Index 8/18/08 8112108 Net Change %Change San Diego Business 1790.46 1796.34 -5.88 -0.33%

Journal Index Dow Jones 11348.55 11642.47 -293.92 -2.52%

Industrial Average S&P 500 Index 1266.69 1289.59 -22.9 -1.78% NASDAQ Composite 2384.36 2430.61 -46.25 -1.90% Market Trends Date SDDJ S&P 500 NASDAQ DJI 8/19/2008 1790.46 1266.69 2384.36 11348.55 8/12/2008 1796.34 1289.59 2430.61 11642.47 8/5/2008 1804.77 1284.88 2349.83 11615.77 7/29/2008 1775.40 1263.19 2319.62 11397.56 7/22/2008 1554.20 1277.00 2303.96 11602.50 7/15/2008 1578.88 1214.91 2215.71 10962.54 7/8/2008 1597.98 1273.70 2294.44 11384.21 7/1/2008 1567.63 1284.91 2304.97 11382.26 Top Dollar Gainers Illumina Inc. 2.20 Micromet Inc. 1.86 Imperial Capital Bancorp Inc. 0.89 Rubio's Restaurants Inc. 0.83 Sequenom Inc. 0.79 Top Percentage Gainers Micromet Inc. 46.04% Nitches Inc. 28.40% Dalrada Financial Corp. 16.67% Rubio's Restaurants Inc. 15.04% Royale Energy Inc. 12.11% Top Dollap Losers NuVasive Inc. -5.26 Amylin Pharmaceuticals Inc. -4.72 WD-40 Co. -2.55 PacWest Bancorp. -2.29 Gen-Probe Inc. -2.01 Top Percentage Losers MAR Technologies Inc. -22.22% Microlslet Inc. -16.67% Nanogen Inc. -15.38% Amylin Pharmaceuticals Inc. -14.20% Javo Beverage Co. Inc. -13.85% Market Recap Advancers 25 Decliners 60 Unchanged 4 EXCH- TICKER PRICE PRICE ANGE SYMBOL COMPANY NAME 8/19/2008 8/12/2008 NASD FPBN 1ST PACIFIC BANCORP 6.85 7.40 NASD ACAD ACADIA PHARMACEUTICALS INC. 2.91 3.11 NASD ACCL ACCELRYS INC. 5.13 5.20 AMEX ANX ADVENTRX PHARMACEUTICALS 0.28 0.29

INC. NASD ALDA ALDILA INC. 3.92 4.12 NASD ATEC ALPHATECH HOLDINGS INC. 4.99 5.05 NASD ATCO AMERICAN TECHNOLOGY CORP. 1.03 1.13 NYSE AHS AMN HEALTHCARE SERVICES INC. 18.11 17.68 NASD AMLN AMYLIN PHARMACEUTICALS INC. 28.51 33.23 NASD ANDS ANADYS PHARMACEUTICALS INC. 2.40 2.78 NASD ARNA ARENA PHARMACEUTICALS INC. 6.32 6.16 NASD ASHW ASHWORTH INC. 3.04 3.47 NASD AVNR AVANIR PHARMACEUTICALS 0.93 0.97 AMEX AFT AXESSTEL INC. 0.98 1.00 NYSE BMR BIOMED REALTY TRUST INC. 25.75 26.73 NASD CADX CADENCE PHARMACEUTICALS INC. 9.26 10.00 NYSE ELY GALLAWAY GOLF CO. 13.65 14.31 NASD CDIC CARDIODYNAMICS 1.31 1.38

INTERNATIONAL CORP. AMEX CXM CARDIUM THERAPEUTICS INC. 1.97 2.05 NASD CHIC CHARLOTTE RUSSE HOLDING INC. 12.47 12.52 NASD COHU COHU INC. 17.27 18.23 AMEX CUB CUBIC CORP. 29.16 28.81 NASD CYMI CYMER INC. 30.36 31.10 NASD CYPB CYPRESS BIOSCIENCES INC. 6.73 7.22 OTC DFCO.PK DALRADA FINANCIAL CORP. 0.07 0.06 NASD DXCM DEXCOM INC. 6.25 6.45 NASD DRAD DIGIRAD CORP. 1.90 1.79 NASD DEIX DEI HOLDINGS INC. 1.50 1.70 NASD DIVX DIVX INC. 8.32 8.25 NASD HILL DOT HILL SYSTEMS CORP. 2.24 2.42 NASD ECPG ENCORE CAPITAL GROUP INC. 10.87 11.69 NASD FPTB FIRST PACTRUST BANCORP INC. 11.50 11.40 NASD GXDX GENOPTIX INC. 35.44 35.42 NASD GPRO GEN-PROBE INC. 58.19 60.20 NASD HALO HALOZYME THERAPEUTICS 7.14 7.63 NASD HEPH HOLLIS-EDEN PHARMACEUTICALS 1.64 1.64

INC. NASD IDMI IDM PHARMA INC. 3.30 2.95 NASD ILMN ILLUMINA INC. 92.57 90.37 OTC IWSY.OB IMAGEWAKE SYSTEMS INC. 0.50 0.45 NYSE IMP IMPERIAL CAPITAL 11.08 10.19

BANCORP INC. NASD IFON INFOSONICS CORP. 0.68 0.74 AMEX INO INOVIO BIOMEDICAL CORP. 0.96 0.98 NASD IVGN INVITROGEN CORP. 42.83 43.94 NASD ISIS ISIS PHARMACEUTICALS INC. 18.15 18.79 NYSE JBX JACK IN THE BOX INC. 24.91 25.89 OTC JAVO.OB JAVO BEVERAGE CO. INC. 0.56 0.65 OTC JMAR.OB JMAR TECHNOLOGIES INC. 0.14 0.18 NASD KTOS KRATOS DEFENSE & SECURITY 1.99 1.85

SOLUTIONS INC. NASD WPC LAJOLLA PHARMACEUTICAL CO. 2.00 1.94 NASD LEAP LEAP WIRELESS INTERNATIONAL 40.79 42.78

INC. NASD MXWL MAXWELL TECHNOLOGIES INC. 12.22 13.07 NASD MNOV MEDICINOVA INC. 3.67 3.70 NASD MBRX METABASIS THERAPEUTICS INC. 1.55 1.43 OTC MIIS.OB MICROISLET INC. 0.25 0.30 NASD MITI MICROMET INC. 5.90 4.04 NASD NGEN NANOGEN INC. 0.33 0.39 NASD NAII NATURAL ALTERNATIVES 7.57 7.97

INTERNATIONAL INC. NASD NBIX NEUROCRINE BIOSCIENCES INC. 4.70 4.70 NASD NICH NITCHES INC. 1.04 0.81 NASD NVTL NOVATEL WIRELESS INC. 8.40 9.16 AMEX NTN NTN BUZZTIME INC. 0.32 0.32 NASD NUVA NUVASIVE INC. 50.75 56.01 NASD OPTR OPTIMER PHARMACEUTICALS INC. 8.17 9.35 NASD OREX OREXIGEN THERAPEUTICS INC. 10.37 10.42 NASD OVRL OVERLAND STORAGE INC. 0.98 1.08 NASD PACW PACWEST BANCORP. 20.41 22.70 OTC PTSC.OB PATRIOT SCIENTIFIC CORP. 0.24 0.26 AMEX PXG PHOENIX FOOTWEAR GROUP INC. 1.19 1.10 NASD PICO PICO HOLDINGS INC. 45.74 46.83 NASD PSMT PRICESMART INC. 21.53 22.83 NASD PURE PURE BIOSCIENCE 4.59 4.97 NASD QCOM QUALCOMM INC. 54.79 54.21 NASD ODEL QUIDEL CORP. 19.48 20.00 NYSE O REALTY INCOME CORP. 25.11 25.30 NYSE RMD RESMED INC. 44.20 44.45 NASD RFIL RF INDUSTRIES LTD. 7.90 7.52 NASD ROYL ROYALE ENERGY INC. 6.39 5.70 NASD BUBO RUBIO'S RESTAURANTS INC. 6.35 5.52 NYSE SAI SAIC INC. 19.19 18.90 NASD SLATS SANTARUS INC. 2.46 2.51 NYSE SRE SEMPRA ENERGY 56.77 56.66 NASD SNMX SENOMYX INC. 3.90 4.39 NASD SQNM SEQUENOMINC. 20.50 19.71 OTC SHSO.PK SOUND HEALTH SOLUTIONS 0.02 0.02 OTC TDLPOB TRANSDEL PHARMACEUTICALS 1.50 1.60

INC. NASD VSAT VIASAT INC. 26.30 27.74 NASD VICL VICAL INC. 3.29 3.51 NASD WDFC WD-40 CO. 34.89 37.44 NASD WBSN WEBSENSE INC. 22.53 22.60

NET PERCENT 52-WEEK COMPANY NAME CHANGE CHANGE HIGH 1ST PACIFIC BANCORP -0.55 -7.43% 15.50 ACADIA PHARMACEUTICALS INC. -0.2 -6.43% 16.56 ACCELRYS INC. -0.07 -1.35% 8.24 ADVENTRX PHARMACEUTICALS -0.01 -3.45% 2.70