Public companies: headquarters in San Diego County; ranked by fiscal 2007 revenues.

PUBLIC COMPANIES Headquarters in San Diego County; ranked by fiscal 2007 revenues

Revenue:

Millions

* 2007 Rank * 2006 Net income (last Company * % change 2007 (loss) Fiscal year) Web site (loss) $ Millions year-end 1 Sempra Energy $11,438.1 $1,099.0 12/31/2007 (1) www.sempra.com $11,761.0

(2.7) 2 Qualcommom Inc. $8,871.0 $3,303.0 9/30/2007 (3) www.qualcommom.com $7,526.0

17.9 3 SAIC $8,061.1 $391.0 1/31/2007 (2) www.saic.com $7,518.0

7.2 4 Jack in the Box Inc. $2,876.0 $126.3 10/1/2007 (4) www.jackinthebox.com $2,723.6

5.6 5 Leap Wireless $1,630.8 ($75.9) 12/31/2007 (6) International Inc. $1,167.2

www.leapwireless.com 39.7 6 Invitrogen Corp. $1,281.7 $143.2 12/31/2007 (5) www.invitrogen.com $1,151.2

11.3 7 AMN Healthcare $1,164.0 $36.5 12/31/2007 (7) Services Inc. $1,081.7

www.amnhealthcare.com 7.6 8 Callaway Golf Co. $1,124.6 $54.6 12/31/2007 (9) www.callawaygolf.com $1,081.7

10.5 9 Cubic Corp. $889.9 $41.6 9/30/2007 (10) www.cubic.com $821.4

8.3 10 PriceSmart Inc. $888.8 $12.9 8/31/2007 (11) www.pricesmart.com $734.7

21.0 11 Amylin Pharma- $781.0 ($211.1) 12/31/2007 (15) ceuticals Inc. $510.9

www.amylin.com 52.9 12 Charlotte Russe $740.9 $36.3 9/30/2007 (12) Holding Inc. $681.5

www.charlotte- 8.7

russe.com 13 ResMed Inc. $716.3 $66.3 6/30/2007 (13) www.resmed.com $607.0

18.0 14 Cymer Inc. $521.8 $88.4 12/31/2007 (14) www.cymer.com $543.9

(4.1) 15 ViaSat Inc. $516.6 $30.2 3/30/2007 (17) www.viasat.com $433.8

19.1 16 Novatel Wireless Inc. $429.9 $38.8 12/31/2007 (30) www.novatelwireles.com $218.0

97.2 17 Gen-Probe Inc. $403.0 $86.1 12/31/2007 (19) www.gen-probe.com $354.8

13.6 18 DEI Holdings Inc. (1) $401.1 -$140.0 12/31/2007 (16) www.deiholdings.com $437.8

(8.4) 19 PacWest Bancorp (2) $383.9 $90.3 12/31/2007 (20) www.firstcommunity- $318.1

bancorp.com 20.7 20 Illumina Inc. $366.8 -$278.4 12/31/2007 (33) www.illumina.com $184.6

98.7 21 WD-40 Co. $307.8 $31.5 8/31/2007 (21) www.wd40company.com 286.9

7.3 22 Realty Income Corp. $296.5 $140.4 12/31/2007 (25) www.realtyincome.com $239.5

23.8 23 BioMed Really $266.1 $72.5 12/31/2007 (29) Trust Inc. $218.7

www.biomedrealty.com 21.7 24 Imperial Capital $254.4 $15.6 12/31/2007 (28) Bancorp Inc. $229.3

www.itlacapital.com 11.0 25 Encore Capital $254.0 $15.0 12/31/2007 (23) Group Inc. $255.1

www.mcmcg.com (0.4) 26 InfoSonics Corp. $244.7 ($1.6) 12/31/2007 (24) www.infosonics.com $240.9

1.6 27 Cohu Inc. $241.4 $8.0 12/30/2007 (22) www.cohu.com $270.1

(10.6) 28 Cohu Inc. $211.6 ($14.6) 12/31/2007 (34) www.webwebsense.com $178.8

18.3 29 Dot Hill Systems Corp. $207.1 ($60.2) 12/31/2007 (26) www.dothill.com 239.2

(13.4) 30 Ashworth Inc. $202.2 ($14.1) 10/31/2007 (31) www.ashworthinc.com $209.6

(3.5) 31 Kratos Defense & $193.6 ($40.8) 12/31/2007 (NR) Security Solutions $153.1

Inc. (1) 26.5

www.kratosdefense.com 32 Rubio's Restaurants $169.7 $1.2 12/31/2007 (35) Inc. $152.3

www.rubios.com 11.5 33 Overland Storage Inc. $160.4 ($44.1) 7/1/2007 (32) www.overland- $209.0

storage.com (23.2) 34 NuVasive Inc . $154.3 ($11.3) 12/31/2007 (39) www.nuvasive.com $98.1

57.3 35 Quidel Corp. $118.1 $13.6 12/31/2007 (37) www.quidel.com $106.0

11.4 36 Natural Alternatives $97.1 ($5.3) 6/30/2007 (38) International Inc. $99.6

www.nai-online.com (2.5) 37 Santarus Inc. $94.4 $44.3 12/31/2007 (51) www.santarus.com $49.2

91.8 38 Nitches Inc. $84.9 $0.9 8/31/2007 (49) www.nitches.com $54.8

54.9 39 DivX Inc. $84.9 $9.2 12/31/2007 (47) www.divx.com $59.3

43.0 40 Phoenix Footwear $82.9 ($1.3) 12/30/2007 (36) Group Inc. $95.5

www.phoenix- (5.3)

footwear.com 41 Axesstel Inc. $82.4 ($9.0) 12/31/2007 (40) www.axesstel.com $95.5

(13.7) 42 Accelrys Inc. $81.0 ($1.5) 3/31/2007 (42) www.accelrys.com $82.0

(1.3) 43 Alphatech Holdings $80.0 ($20.2) 12/31/2007 (NR) Inc. $74.0

na 8.1 44 SYS Technologies $75.8 ($1.7) 6/30/2007 (48) Inc. (1) $55.9

www.systechnolo- 35.7

gies.com 45 Digirad Corp. $73.9 ($1.4) 12/3112007 (44) www.digirad.com 71.9

2.8 46 Isis Pharmaceuticals $69.6 $11.0 12/31/2007 (63) Inc. $24.5

www.isispharm.com 183.8 47 Aldila Inc. $69.1 $16.0 12/31/2007 (43) www.aldila.com $72.4

(4.5) 48 Genoptix Inc. $59.3 $13.4 12/31/2007 (NR) www.genoptix.com $24.0

147.0 49 Maxwell Technologies $57.4 $15.7 12/31/2007 (50) Inc. 53.9

www.maxwell.com 6.5 50 First Pactrust $48.1 $3.0 12/31/2007 (52) Bancorp Inc. $47.7

www.pacifictrust- 0.8

bank.com 51 Sequenom Inc. $41.0 ($22.0) 12/31/2007 (59) www.sequenom.com $28.5

43.9 52 Nanogen Inc. $38.2 ($33.9) 12/31/2007 (61) www.nanogen.com $26.9

42.2 53 Pico Holdings Inc. $33.9 ($1.3) 12/31/2007 (41) www.picoholdings.com $82.7

(59.0) 54 NTN Buzztime Inc. $30.5 $5.0 12/31/2007 (56) www.ntnbuzztime.com $33.0

(7.4) 55 1st Pacific Bancorp $29.9 $2.5 12131/2007 (NR) www.1stpacbank.com $24.0

24.6 56 Anadys Pharmaceuti- $24.1 ($9.2) 12/31/2007 (72) cals Inc. $5.4

www.anadyspharma.com 345.0 57 CardioDynamics $21.9 ($16.7) 11/30/2007 (58) International Corp. $30.3

www.cardiodynamics.com (28.0) 58 Arena Pharmaceuticals $19.3 ($143.2) 12/31/2007 (57) Inc. $30.6

www.arenapharm.com (36.8) 59 Micromet Inc. $18.4 ($20.1) 12/31/2007 (60) www.micromet-inc.com $27.3

(33.4) 60 Senomyx Inc. $18.2 ($21.8) 12/31/2007 (67) www.senomyx.com $12.2

49.0 61 Royale Energy Inc. $16.6 ($2.8) 12131/2007 (62) www.royl.com $24.9

(33.5) 62 RF Industries Inc. $14.9 $1.1 10/31/2007 (64) www.rfindustries.com $15.2

(2.2) 63 IDM Pharma Inc. $14.6 ($18.4) 12/31/2007 (68) www.idm-biotech.com $11.3

29.6 64 Cypress Biosciences $13.9 $3.5 12/31/2007 (75) Inc. $4.3

www.cypressbio.com 222.6 65 American Technology $9.9 ($5.6) 9/30/2007 (70) Corp. $9.9

www.atcsd.com 0.0 66 Metabasis $9.0 ($41.8) 12/31/2007 (74) Therapeutics Inc. $4.4

www.mbasis.com 105.6 67 Acadia $7.6 ($56.4) 12/31/2007 (71) Pharmaceuticals Inc. $8.1

www.acadia-pharm.com (7.1) 68 Vical Inc. $5.5 ($35.9) (66) www.vical.com $14.7 12/31/2007

(62.6) 69 Inovio Biomedical $4.8 ($11.2) 12/31/2007 (NR) Corp. $3.5

www.inovio.com 38.6 70 DexCom Inc. $4.6 ($45.9) 12/31/2007 (76) www.dexcom.com $2.2

113.2 71 Halozyme Therapeutics $3.8 ($23.9) 12/31/2007 (77) www.halozyme.com $1.0

287.0 72 Cardium Therapeutics $1.6 ($25.3) 12/31/2007 (79) Inc. $0.8

www.cardiumthx.com 109.9 73 Neurocrine $1.2 ($207.3) 12/31/2007 (54) Biosciences Inc. $39.2

www.neurocrine.com (96.9) 74 JMAR Technologies Inc. $0.9 ($1.6) 12/31/2007 (73) www.jmar.com $2.0

(56.5) 75 Optimer Pharmaceu- $0.8 ($46.1) 12/31/2007 (78) ticals Inc. $0.9

www.optimer.com (17.8) 76 MicroIslet Inc. $0.7 ($9.4) 12/31/2007 (80) www.microislet.com $0.6

17.6 77 Hollis-Eden $0.7 ($23.1) 12/31/2007 (8i) Pharmaceuticals Inc. $0.6

www.holliseden.com 45.3 78 Patriot Scientific $0.64 $23.7 5/31/2008 (NR) Corp. $10.3

www.ptsc.com (93.8) 79 Adventrx Pharmaceu- $0.5 ($22.1) 12/31/2007 (NR) ticals Inc. $0.0

www.adventrx.com na 80 Pure Bioscience $0.3 ($4.7) (NR) www.purebio.com $0.2 7/31/2008

68.0 81 Orexigen Therapeutics $0.1 ($57.8) 12/31/200 (83) Inc. $0.1

www.orexigen.com 0.0 82 Transdel Pharmaceuti- $0.0 ($4.3) 12/31/2007 (NR) cals Inc. $0.0

www.transdelpharma.com NA 83 Medicinova Inc. $0.0 ($48.9) 12/31/2007 (82) www.medicinova.com $0.3

(100.0) 84 Cadence Pharmaceuti- $0.0 ($51.7) 12/31/2007 (86) cals Inc. $0.0

www.cadencepharm.com NA 85 La Jolla $0.0 ($53.1) 12/31/2007 (85) Pharmaceutical Co. $0.0

www.ljpc.com NA

Shares Aggregate Rank outstanding market (last Company as of value * Exchange year) Web site 6/30/08 $ Millions * Symbol 1 Sempra Energy 250,340.0 $14.1 NYSE (1) www.sempra.com SRE 2 Qualcommom Inc. 1,620,000.0 $71.9 Nasdaq (3) www.qualcommom.com QCOM 3 SAIC 407,070.0 $8.5 NYSE (2) www.saic.com SAI 4 Jack in the Box Inc. 58,760.0 $1.3 NYSE (4) www.jackinthebox.com JBX 5 Leap Wireless 68,990.0 $3.0 Nasdaq (6) International Inc. LEAP

www.leapwireless.com 6 Invitrogen Corp. 89,480.0 $3.5 Nasdaq (5) www.invitrogen.com IVGN 7 AMN Healthcare 33,830.0 $0.6 NYSE (7) Services Inc. AHS

www.amnhealthcare.com 8 Callaway Golf Co. 64,660.0 $0.8 NYSE (9) www.callawaygolf.com ELY 9 Cubic Corp. 26,720.0 $0.6 AMEX (10) www.cubic.com CUB 10 PriceSmart Inc. 29,690.0 $0.6 Nasdaq (11) www.pricesmart.com PSMT 11 Amylin Pharma- 137,070.0 $3.5 Nasdaq (15) ceuticals Inc. AMLN

www.amylin.com 12 Charlotte Russe 20,850.0 $0.4 Nasdaq (12) Holding Inc. CHIC

www.charlotte-

russe.com 13 ResMed Inc. 77,260.0 $2.8 NYSE (13) www.resmed.com RMD 14 Cymer Inc. 30,350.0 $0.8 Nasdaq (14) www.cymer.com CYMI 15 ViaSat Inc. 30,490.0 $0.6 Nasdaq (17) www.viasat.com VSAT 16 Novatel Wireless Inc. 32,540.0 $0.4 Nasdaq (30) www.novatelwireles.com NVTL 17 Gen-Probe Inc. 54,000.0 $2.6 Nasdaq (19) www.gen-probe.com GPRO 18 DEI Holdings Inc. (1) 25,470.0 $0.0 Nasdaq (16) www.deiholdings.com DEIX 19 PacWest Bancorp (2) 27,170.0 $0.4 Nasdaq (20) www.firstcommunity- PACW

bancorp.com 20 Illumina Inc. 56,420.0 $4.9 Nasdaq (33) www.illumina.com ILMN 21 WD-40 Co. 16,430.0 $0.5 Nasdaq (21) www.wd40company.com WDFC 22 Realty Income Corp. 101,300.0 $2.3 NYSE (25) www.realtyincome.com O 23 BioMed Really 71,720.0 $1.8 NYSE (29) Trust Inc. BMR

www.biomedrealty.com 24 Imperial Capital 5,430.0 $0.0 NYSE (28) Bancorp Inc. IMP

www.itlacapital.com 25 Encore Capital 22,990.0 $0.2 Nasdaq (23) Group Inc. ECPG

www.mcmcg.com 26 InfoSonics Corp. 14,910.0 $0.0 Nasdaq (24) www.infosonics.com IFON 27 Cohu Inc. 23,060.0 $0.3 Nasdaq (22) www.coh cohu.com COHU 28 Cohu Inc. 45,130.0 $0.8 Nasdaq (34) www.webwebsense.com WBSN 29 Dot Hill Systems Corp. 46,050.0 $0.1 Nasdaq (26) www.dothill.com HILL

14,710.0 $0.1 Nasdaq 30 Ashworth Inc. ASHW (31) www.ashworthinc.com 31 Kratos Defense & 79,700.0 $0.2 Nasdaq (NR) Security Solutions KTOS

Inc. (1)

www.kratosdefense.com 32 Rubio's Restaurants 9,950.0 $0.0 Nasdaq (35) Inc. RUBO

www.rubios.com 33 Overland Storage Inc. 12,760.0 $0.0 Nasdaq (32) www.overland- OVRL

storage.com 34 NuVasive Inc . 35,570.0 $0.4 Nasdaq (39) www.nuvasive.com NUVA 35 Quidel Corp. 32,340.0 $0.5 Nasdaq (37) www.quidel.com ODEL 36 Natural Alternatives 7,020.0 $0.1 Nasdaq (38) International Inc. NAII

www.nai-online.com 37 Santarus Inc. 51,320.0 $0.1 Nasdaq (51) www.santarus.com SNTS 38 Nitches Inc. 6,020.0 $1.3 Nasdaq (49) www.nitches.com NIGH 39 DivX Inc. 32,380.0 $0.0 Nasdaq (47) www.divx.com DIVX 40 Phoenix Footwear 8,170.0 $0.0 AMEX (36) Group Inc. PXG

www.phoenix-

footwear.com 41 Axesstel Inc. 23,230.0 $0.0 AMEX (40) www.axesstel.com AFT 42 Accelrys Inc. 26,790.0 $0.1 Nasdaq (42) www.accelrys.com ACCL 43 Alphatech Holdings 47,400.0 $0.2 Nasdaq (NR) Inc. ATEC

na 44 SYS Technologies 19,900.0 $0.3 AMEX (48) Inc. (1) SYS

www.systechnolo-

gies.com 45 Digirad Corp. 18,930.0 $0.0 Nasdaq (44) www.digirad.com DRAD 46 Isis Pharmaceuticals 95,380.0 $0.0 Nasdaq (63) Inc. ISIS

www.isispharm.com 47 Aldila Inc. 5,160.0 $3.0 Nasdaq (43) www.aldila.com ALDA 48 Genoptix Inc. 16,340.0 $0.0 Nasdaq (NR) www.genoptix.com GXDX 49 Maxwell Technologies 20,820.0 $0.1 Nasdaq (50) Inc. MXWL

www.maxwell.com 50 First Pactrust 4,320.0 $0.2 Nasdaq (52) Bancorp Inc. FPTB

www.pacifictrust-

bank.com 51 Sequenom Inc. 45,410.0 $0.1 Nasdaq (59) www.sequenom.com SQNM 52 Nanogen Inc. 74,460.0 $0.1 Nasdaq (61) www.nanogen.com NGEN 53 Pico Holdings Inc. 18,830.0 $0.8 Nasdaq (41) www.picoholdings.com PICO 54 NTN Buzztime Inc. 55,650.0 $0.0 AMEX (56) www.ntnbuzztime.com NTN 55 1st Pacific Bancorp 4,950.0 $0.0 Nasdaq (NR) www.1stpacbank.com FPBN 56 Anadys Pharmaceuti- 28,700.0 $0.1 Nasdaq (72) cals Inc. ANDS

www.anadyspharma.com 57 CardioDynamics 7,190.0 $0.4 Nasdaq (58) International Corp. CDIC

www.cardiodynamics.com 58 Arena Pharmaceuticals 73,840.0 $0.4 Nasdaq (57) Inc. ARNA

www.arenapharm.com 59 Micromet Inc. 40,830.0 $0.7 Nasdaq (60) www.micromet-inc.com MITT 60 Senomyx Inc. 30,590.0 $0.0 Nasdaq (67) www.senomyx.com SNMX 61 Royale Energy Inc. 7,920.0 $0.0 Nasdaq (62) www.royl.com ROYL 62 RF Industries Inc. 3,290.0 $2.0 Nasdaq (64) www.rfindustries.com RFIL 63 IDM Pharma Inc. 25,170.0 $0.0 Nasdaq (68) www.idm-biotech.com IDMI 64 Cypress Biosciences 37,540.0 $0.1 Nasdaq (75) Inc. CYPB

www.cypressbio.com 65 American Technology 30,540.0 $0.1 Nasdaq (70) Corp. ATCO

www.atcsd.com 66 Metabasis 34,930.0 $0.1 Nasdaq (74) Therapeutics Inc. MBRX

www.mbasis.com 67 Acadia 37,090.0 $0.1 Nasdaq (71) Pharmaceuticals Inc. ACAD

www.acadia-pharm.com 68 Vical Inc. (66) www.vical.com 39,230.0 $0.1 Nasdaq 69 Inovio Biomedical 43,870.0 $0.0 AMEX (NR) Corp. INO

www.inovio.com 70 DexCom Inc. 29,480.0 $0.2 Nasdaq (76) www.dexcom.com DXCM 71 Halozyme Therapeutics 79,520.0 $0.4 Nasdaq (77) www.halozyme.com HALO 72 Cardium Therapeutics 43,630.0 $0.1 AMEX (79) Inc. CXM

www.cardiumthx.com 73 Neurocrine 38,420.0 $0.1 Nasdaq (54) Biosciences Inc. NBIX

www.neurocrine.com 74 JMAR Technologies Inc. 53,880.0 $0.0 OTC (73) www.jmar.com JMAR.OB 75 Optimer Pharmaceu- 27,930.0 $0.2 Nasdaq (78) ticals Inc. OPTR

www.optimer.com 76 MicroIslet Inc. 54,590.0 $0.0 OTC (80) www.microislet.com MIISS.OB 77 Hollis-Eden 29,010.0 $0.0 Nasdaq (8i) Pharmaceuticals Inc. HEPH

www.holliseden.com 78 Patriot Scientific 391,470.0 $0.1 OTC (NR) Corp. PTSC.OB

www.ptsc.com 79 Adventrx Pharmaceu- 90,250.0 $0.0 AMEX (NR) ticals Inc. ANX

www.adventrx.com 80 Pure Bioscience Nasdaq (NR) www.purebio.com 29,300.0 $0.1 PURE 81 Orexigen Therapeutics 34,310.0 $0.0 Nasdaq (83) Inc. OREX

www.orexigen.com 82 Transdel Pharmaceuti- 15,550.0 $0.0 OTC (NR) cals Inc. TDLP.OB

www.transdelpharma.com 83 Medicinova Inc. 11,960.0 $0.1 Nasdaq (82) www.medicinova.com MNOV 84 Cadence Pharmaceuti- 38,350.0 $0.2 Nasdaq (86) cals Inc. CADX

www.cadencepharm.com 85 La Jolla 39,670.0 $0.1 Nasdaq (85) Pharmaceutical Co. LJPC

www.ljpc.com Rank (last Company 52-week 52-week Earnings per year) Web site high low share (loss) 1 Sempra Energy $64.21 $48.58 $4.24 (1) www.sempra.com 2 Qualcommom Inc. $50.82 $35.17 $1.99 (3) www.qualcommom.com 3 SAIC $21.90 $16.11 $1.11 (2) www.saic.com 4 Jack in the Box Inc. $36.85 $22.33 $1.93 (4) www.jackinthebox.com 5 Leap Wireless $99.04 $29.87 ($1.13) (6) International Inc.

www.leapwireless.com 6 Invitrogen Corp. $49.58 $35.12 $3.07 (5) www.invitrogen.com 7 AMN Healthcare $22.38 $14.25 $1.06 (7) Services Inc.

www.amnhealthcare.com 8 Callaway Golf Co. $19.49 $11.57 $0.82 (9) www.callawaygolf.com 9 Cubic Corp. $50.68 $21.03 $1.56 (10) www.cubic.com 10 PriceSmart Inc. $33.67 $19.17 $0.45 (11) www.pricesmart.com 11 Amylin Pharma- $53.25 $23.75 ($1.59) (15) ceuticals Inc.

www.amylin.com 12 Charlotte Russe $27.14 $12.27 $1.44 (12) Holding Inc.

www.charlotte-

russe.com 13 ResMed Inc. $54.58 $20.51 $0.86 (13) www.resmed.com 14 Cymer Inc. $44.73 $22.86 $2.64 (14) www.cymer.com 15 ViaSat Inc. $36.49 $19.06 $1.06 (17) www.viasat.com 16 Novatel Wireless Inc. $29.14 $7.42 $1.23 (30) www.novatelwireles.com 17 Gen-Probe Inc. $71.84 $44.82 $1.63 (19) www.gen-probe.com 18 DEI Holdings Inc. (1) $9.06 $0.99 ($5.40) (16) www.deiholdings.com 19 PacWest Bancorp (2) $62.56 $14.85 $3.16 (20) www.firstcommunity-

bancorp.com 20 Illumina Inc. $90.38 $40.04 ($5.14) (33) www.illumina.com 21 WD-40 Co. $42.70 $28.91 $1.85 (21) www.wd40company.com 22 Realty Income Corp. $30.70 $20.27 $1.16 (25) www.realtyincome.com 23 BioMed Really $27.75 $19.32 $0.83 (29) Trust Inc.

www.biomedrealty.com 24 Imperial Capital $54.11 $5.73 $2.85 (28) Bancorp Inc.

www.itlacapital.com 25 Encore Capital $12.81 $6.10 $0.66 (23) Group Inc.

www.mcmcg.com 26 InfoSonics Corp. $3.80 $0.68 ($0.11) (24) www.infosonics.com 27 Cohu Inc. $23.70 $13.27 $0.35 (22) www.coh cohu.com 28 Cohu Inc. $23.10 $15.43 ($0.32) (34) www.webwebsense.com 29 Dot Hill Systems Corp. $4.12 $2.04 ($1.32) (26) www.dothill.com 30 Ashworth Inc. $7.49 $2.47 ($0.97) (31) www.ashworthinc.com 31 Kratos Defense & $3.09 $1.50 ($0.55) (NR) Security Solutions

Inc. (1)

www.kratosdefense.com 32 Rubio's Restaurants $12.02 $4.53 $0.12 (35) Inc.

www.rubios.com 33 Overland Storage Inc. $2.88 $0.93 ($3.45) (32) www.overland-

storage.com 34 NuVasive Inc . $46.06 $25.93 ($0.32) (39) www.nuvasive.com 35 Quidel Corp. $21.07 $12.95 $0.43 (37) www.quidel.com 36 Natural Alternatives $9.20 $5.64 ($0.77) (38) International Inc.

www.nai-online.com 37 Santarus Inc. $5.83 $1.78 $0.87 (51) www.santarus.com 38 Nitches Inc. $417.00 $0.97 $18.00 (49) www.nitches.com 39 DivX Inc. $19.35 $6.12 $0.27 (47) www.divx.com 40 Phoenix Footwear $4.45 $1.10 ($0.17) (36) Group Inc.

www.phoenix-

footwear.com 41 Axesstel Inc. $1.44 $0.19 ($0.39) (40) www.axesstel.com 42 Accelrys Inc. $824.00 $4.81 ($0.06) (42) www.accelrys.com 43 Alphatech Holdings $6.53 $3.32 ($0.54) (NR) Inc.

na 44 SYS Technologies $2.52 $1.30 ($0.10) (48) Inc. (1)

www.systechnolo-

gies.com 45 Digirad Corp. $4.68 $2.05 ($0.07) (44) www.digirad.com 46 Isis Pharmaceuticals $20.15 $9.52 $1.63 (63) Inc.

www.isispharm.com 47 Aldila Inc. $18.36 $5.73 $2.94 (43) www.aldila.com 48 Genoptix Inc. $37.88 $20.41 $1.20 (NR) www.genoptix.com 49 Maxwell Technologies $16.50 $7.10 $0.86 (50) Inc.

www.maxwell.com 50 First Pactrust $26.35 $12.00 $0.71 (52) Bancorp Inc.

www.pacifictrust-

bank.com 51 Sequenom Inc. $16.89 $4.25 ($0.57) (59) www.sequenom.com 52 Nanogen Inc. $1.99 $0.27 ($0.47) (61) www.nanogen.com 53 Pico Holdings Inc. $48.87 $28.62 ($0.07) (41) www.picoholdings.com 54 NTN Buzztime Inc. $1.04 $0.26 $0.09 (56) www.ntnbuzztime.com 55 1st Pacific Bancorp $15.50 $7.27 $0.56 (NR) www.1stpacbank.com 56 Anadys Pharmaceuti- $3.88 $1.36 ($0.32) (72) cals Inc.

www.anadyspharma.com 57 CardioDynamics $4.62 $0.70 ($0.34) (58) International Corp.

www.cardiodynamics.com 58 Arena Pharmaceuticals $14.78 $4.55 ($2.31) (57) Inc.

www.arenapharm.com 59 Micromet Inc. $2.95 $1.22 ($0.55) (60) www.micromet-inc.com 60 Senomyx Inc. $14.00 $4.35 ($0.72) (67) www.senomyx.com 61 Royale Energy Inc. $14.70 $2.18 ($0.35) (62) www.royl.com 62 RF Industries Inc. $8.50 $5.20 $0.35 (64) www.rfindustries.com 63 IDM Pharma Inc. $3.88 $0.57 ($0.87) (68) www.idm-biotech.com 64 Cypress Biosciences $15.60 $6.17 $0.10 (75) Inc.

www.cypressbio.com 65 American Technology $4.50 $1.09 ($0.18) (70) Corp.

www.atcsd.com 66 Metabasis $7.15 $1.40 ($1.37) (74) Therapeutics Inc.

www.mbasis.com 67 Acadia $17.33 $3.55 ($1.60) (71) Pharmaceuticals Inc.

www.acadia-pharm.com 68 Vical Inc. (66) www.vical.com $5.53 $3.00 ($0.92) 69 Inovio Biomedical $322.00 $0.50 ($0.27) (NR) Corp.

www.inovio.com 70 DexCom Inc. $10.91 $3.69 ($1.62) (76) www.dexcom.com 71 Halozyme Therapeutics $10.50 $4.19 ($0.32) (77) www.halozyme.com 72 Cardium Therapeutics $3.19 $1.50 ($0.64) (79) Inc.

www.cardiumthx.com 73 Neurocrine $13.07 $4.11 ($5.45) (54) Biosciences Inc.

www.neurocrine.com 74 JMAR Technologies Inc. $0.28 $0.04 ($0.07) (73) www.jmar.com 75 Optimer Pharmaceu- $10.42 $5.85 ($2.12) (78) ticals Inc.

www.optimer.com 76 MicroIslet Inc. $74.00 $21.00 ($0.18) (80) www.microislet.com 77 Hollis-Eden $2.87 $1.40 ($0.80) (81) Pharmaceuticals Inc.

www.holliseden.com 78 Patriot Scientific $0.94 $0.17 $0.06 (NR) Corp.

www.ptsc.com 79 Adventrx Pharmaceu- $2.85 $0.33 ($0.25) (NR) ticals Inc.

www.adventrx.com 80 Pure Bioscience $8.72 $2.58 ($0.19) (NR) www.purebio.com 81 Orexigen Therapeutics $18.45 $6.80 ($3.08) (83) Inc.

www.orexigen.com 82 Transdel Pharmaceuti- $3.50 $1.05 ($0.48) (NR) cals Inc.

www.transdelpharma.com 83 Medicinova Inc. $9.02 $3.27 ($4.16) (82) www.medicinova.com 84 Cadence Pharmaceuti- $15.70 $4.84 ($1.81) (86) cals Inc.

www.cadencepharm.com 85 La Jolla $5.59 $1.45 ($1.40) (85) Pharmaceutical Co.

www.ljpc.com Rank (last Company Principal Business year) Web site w/title(s) description 1 Sempra Energy Donald Felsinger Provides electric, (1) www.sempra.com chairman, CEO natural gas,

broadband and

related products

and services 2 Qualcommom Inc. Paul Jacobs Provider of (3) www.qualcommom.com president, CEO wireless

technologies and

services 3 SAIC Kenneth Dahlberg na (2) www.saic.com chairman, CEO 4 Jack in the Box Inc. Linda Lang Ownership, (4) www.jackinthebox.com chairman CEO operation and

franchising of

restaurants under

the name of Jack

in the Box 5 Leap Wireless Stewart Douglas Wireless (6) International Inc. Hutcheson communications

www.leapwireless.com CEO center 6 Invitrogen Corp. Gregory Lucier Biotechnology (5) www.invitrogen.com chairman, CEO company 7 AMN Healthcare Susan Nowakowski Temporary health (7) Services Inc. CEO care staffing

www.amnhealthcare.com company 8 Callaway Golf Co. Ronald Beard Manufacturer of (9) www.callawaygolf.com chairman golf clubs and

balls 9 Cubic Corp. Walter Zable Scientific and (10) www.cubic.com chairman, CEO technical

instrument

manufacturer 10 PriceSmart Inc. Robert Price Ownership and (11) www.pricesmart.com CEO operation of

membership shopping

warehouse clubs 11 Amylin Pharma- Daniel Bradbury Develops drug (15) ceuticals Inc. president, CEO candidates

www.amylin.com 12 Charlotte Russe Mark Hoffman Mail-based (12) Holding Inc. CEO specialty retailer

www.charlotte- of apparel and

russe.com accessories 13 ResMed Inc. Peter Farrell Medical appliances (13) www.resmed.com chairman, CEO and equipment

company 14 Cymer Inc. Robert Akins Supplier for (14) www.cymer.com chairman, CEO the semiconductor

industry 15 ViaSat Inc. Mark Dankberg Provides advanced (17) www.viasat.com chairman, CEO digital satellite

communications and

other wireless

equipment and

services 16 Novatel Wireless Inc. Peter Leparulo Provides wireless (30) www.novatelwireles.com chairman broadband access

solutions 17 Gen-Probe Inc. Henry Nordhoff Biotechnology (19) www.gen-probe.com chairman, CEO research company 18 DEI Holdings Inc. (1) Jim Minarik Consumer (16) www.deiholdings.com CEO electronics

company 19 PacWest Bancorp (2) Matthew Wagner Bank holding (20) www.firstcommunity- CEO company

bancorp.com 20 Illumina Inc. Jay Flatley Biotechnology (33) www.illumina.com president, CEO company 21 WD-40 Co. Garry Ridge Production and (21) www.wd40company.com president, CEO marketing of

various consumer

products 22 Realty Income Corp. Gary Malino Integrated and (25) www.realtyincome.com president, COO self-administered

real estate

investment 23 BioMed Really Alan Gold Real estate (29) Trust Inc. chairman, CEO investment company

www.biomedrealty.com 24 Imperial Capital George Parent of Imperial (28) Bancorp Inc. Haligowski Capital Bank Corp.

www.itlacapital.com chairman, CEO 25 Encore Capital Jay Brandon Purchase and (23) Group Inc. Black management of

www.mcmcg.com CEO charged-off

consumer

receivables

portfolios 26 InfoSonics Corp. Joseph Ram Wireless (24) www.infosonics.com president, CEO telecommuscations

sales 27 Cohu Inc. James Donahue Semiconductor (22) www.coh cohu.com CEO equipment and

materials company 28 Cohu Inc. Gene Hodges Provides employee (34) www.webwebsense.com CEO Internet management

software products 29 Dot Hill Systems Corp. Dana Kammersgard Provides data (26) www.dothill.com president, storage systems for

CEO organizations 30 Ashworth Inc. Allan Fletcher Men's and women's (31) www.ashworthinc.com CEO sports apparel,

headwear and

accessories 31 Kratos Defense & Eric DeMarco Defense and (NR) Security Solutions president, CEO security company

Inc. (1)

www.kratosdefense.com 32 Rubio's Restaurants Daniel Pittard Ownership and (35) Inc. president, CEO operation of

www.rubios.com quick-casual

Mexican restaurants 33 Overland Storage Inc. Vernon LoForb Data storage (32) www.overland- president, CEO device company

storage.com 34 NuVasive Inc . Alexis Lukianov Medical device (39) www.nuvasive.com chairman, CEO company 35 Quidel Corp. Caren Mason Diagnostic (37) www.quidel.com president, CEO solutions

developer 36 Natural Alternatives Mark Ledoux Nutritional (38) International Inc. president, CEO supplement

www.nai-online.com manufacturer 37 Santarus Inc. Gerald Proehl Specialty (51) www.santarus.com president, CEO pharmaceutical

company 38 Nitches Inc. Steven Wyandt Wholesale importer (49) www.nitches.com CEO, CFO and distributor of

clothing 39 DivX Inc. Kevin Hell Digital media (47) www.divx.com president company 40 Phoenix Footwear Cathy Taylor Men's and women's (36) Group Inc. CEO footwear and

www.phoenix- apparel

footwear.com 41 Axesstel Inc. Clark Hickock Communications and (40) www.axesstel.com CEO technology supplier 42 Accelrys Inc. Mark Emkjer Medical software (42) www.accelrys.com chairman development

company 43 Alphatech Holdings na na (NR) Inc.

na 44 SYS Technologies Clifton Cooke Information (48) Inc. (1) president, CEO connectivity

www.systechnolo- solutions

gies.com provider 45 Digirad Corp. Mark Casner Medical-imaging (44) www.digirad.com president, CEO product developer

and manufacturer 46 Isis Pharmaceuticals Stanley Crooke Biopharmaceutical (63) Inc. president, CEO company

www.isispharm.com 47 Aldila Inc. Peter Mathewson Manufacturer of (43) www.aldila.com president, CEO graphite golf

shafts 48 Genoptix Inc. Tina Nova Laboratory service (NR) www.genoptix.com CEO provider 49 Maxwell Technologies David Schramm Energy storage (50) Inc. president, CEO developer and

www.maxwell.com manufacturer 50 First Pactrust Hans Ganz Holding company (52) Bancorp Inc. president, CEO for Pacific

www.pacifictrust- Trust Bank

bank.com 51 Sequenom Inc. Harry Stylli Provider of genetic (59) www.sequenom.com president, CEO analysis products

that translate

science into

solutions 52 Nanogen Inc. Howard Birndorf Provider of human (61) www.nanogen.com CEO molecular

diagnostic products 53 Pico Holdings Inc. John Hart Diversified holding (41) www.picoholdings.com president, CEO company 54 NTN Buzztime Inc. Michael Fleming Interactive (56) www.ntnbuzztime.com president, CEO communications and

entertainment

products 55 1st Pacific Bancorp Ronald Carlson Community business (NR) www.1stpacbank.com chairman, CEO bank 56 Anadys Pharmaceuti- Stephen Worland Biopharmaceutical (72) cals Inc. president, CEO company

www.anadyspharma.com 57 CardioDynamics Michael Perry Medical appliance (58) International Corp. CEO and equipment

www.cardiodynamics.com manufacturer 58 Arena Pharmaceuticals Jack Lief Clinical-stage (57) Inc. president, CEO biopharmaceutical

www.arenapharm.com company 59 Micromet Inc. Christian Itin na (60) www.micromet-inc.com president, CEO 60 Senomyx Inc. Kent Snyder Biotechnology (67) www.senomyx.com CEO company 61 Royale Energy Inc. Donald Hosmer na (62) www.royl.com president, CEO 62 RF Industries Inc. Howard Hill na (64) www.rfindustries.com chairman, CEO 63 IDM Pharma Inc. Timothy Walbert Pharmaceutical (68) www.idm-biotech.com president, CEO company 64 Cypress Biosciences Jay Kranzler Biotechnology (75) Inc. chairman, CEO