San Diego public stocks.

Index Watch Index 8/18/08 8112108 Net Change %Change San Diego Business 1790.46 1796.34 -5.88 -0.33%

Journal Index Dow Jones 11348.55 11642.47 -293.92 -2.52%

Industrial Average S&P 500 Index 1266.69 1289.59 -22.9 -1.78% NASDAQ Composite 2384.36 2430.61 -46.25 -1.90% Market Trends Date SDDJ S&P 500 NASDAQ DJI 8/19/2008 1790.46 1266.69 2384.36 11348.55 8/12/2008 1796.34 1289.59 2430.61 11642.47 8/5/2008 1804.77 1284.88 2349.83 11615.77 7/29/2008 1775.40 1263.19 2319.62 11397.56 7/22/2008 1554.20 1277.00 2303.96 11602.50 7/15/2008 1578.88 1214.91 2215.71 10962.54 7/8/2008 1597.98 1273.70 2294.44 11384.21 7/1/2008 1567.63 1284.91 2304.97 11382.26 Top Dollar Gainers Illumina Inc. 2.20 Micromet Inc. 1.86 Imperial Capital Bancorp Inc. 0.89 Rubio's Restaurants Inc. 0.83 Sequenom Inc. 0.79 Top Percentage Gainers Micromet Inc. 46.04% Nitches Inc. 28.40% Dalrada Financial Corp. 16.67% Rubio's Restaurants Inc. 15.04% Royale Energy Inc. 12.11% Top Dollap Losers NuVasive Inc. -5.26 Amylin Pharmaceuticals Inc. -4.72 WD-40 Co. -2.55 PacWest Bancorp. -2.29 Gen-Probe Inc. -2.01 Top Percentage Losers MAR Technologies Inc. -22.22% Microlslet Inc. -16.67% Nanogen Inc. -15.38% Amylin Pharmaceuticals Inc. -14.20% Javo Beverage Co. Inc. -13.85% Market Recap Advancers 25 Decliners 60 Unchanged 4 EXCH- TICKER PRICE PRICE ANGE SYMBOL COMPANY NAME 8/19/2008 8/12/2008 NASD FPBN 1ST PACIFIC BANCORP 6.85 7.40 NASD ACAD ACADIA PHARMACEUTICALS INC. 2.91 3.11 NASD ACCL ACCELRYS INC. 5.13 5.20 AMEX ANX ADVENTRX PHARMACEUTICALS 0.28 0.29

INC. NASD ALDA ALDILA INC. 3.92 4.12 NASD ATEC ALPHATECH HOLDINGS INC. 4.99 5.05 NASD ATCO AMERICAN TECHNOLOGY CORP. 1.03 1.13 NYSE AHS AMN HEALTHCARE SERVICES INC. 18.11 17.68 NASD AMLN AMYLIN PHARMACEUTICALS INC. 28.51 33.23 NASD ANDS ANADYS PHARMACEUTICALS INC. 2.40 2.78 NASD ARNA ARENA PHARMACEUTICALS INC. 6.32 6.16 NASD ASHW ASHWORTH INC. 3.04 3.47 NASD AVNR AVANIR PHARMACEUTICALS 0.93 0.97 AMEX AFT AXESSTEL INC. 0.98 1.00 NYSE BMR BIOMED REALTY TRUST INC. 25.75 26.73 NASD CADX CADENCE PHARMACEUTICALS INC. 9.26 10.00 NYSE ELY GALLAWAY GOLF CO. 13.65 14.31 NASD CDIC CARDIODYNAMICS 1.31 1.38

INTERNATIONAL CORP. AMEX CXM CARDIUM THERAPEUTICS INC. 1.97 2.05 NASD CHIC CHARLOTTE RUSSE HOLDING INC. 12.47 12.52 NASD COHU COHU INC. 17.27 18.23 AMEX CUB CUBIC CORP. 29.16 28.81 NASD CYMI CYMER INC. 30.36 31.10 NASD CYPB CYPRESS BIOSCIENCES INC. 6.73 7.22 OTC DFCO.PK DALRADA FINANCIAL CORP. 0.07 0.06 NASD DXCM DEXCOM INC. 6.25 6.45 NASD DRAD DIGIRAD CORP. 1.90 1.79 NASD DEIX DEI HOLDINGS INC. 1.50 1.70 NASD DIVX DIVX INC. 8.32 8.25 NASD HILL DOT HILL SYSTEMS CORP. 2.24 2.42 NASD ECPG ENCORE CAPITAL GROUP INC. 10.87 11.69 NASD FPTB FIRST PACTRUST BANCORP INC. 11.50 11.40 NASD GXDX GENOPTIX INC. 35.44 35.42 NASD GPRO GEN-PROBE INC. 58.19 60.20 NASD HALO HALOZYME THERAPEUTICS 7.14 7.63 NASD HEPH HOLLIS-EDEN PHARMACEUTICALS 1.64 1.64

INC. NASD IDMI IDM PHARMA INC. 3.30 2.95 NASD ILMN ILLUMINA INC. 92.57 90.37 OTC IWSY.OB IMAGEWAKE SYSTEMS INC. 0.50 0.45 NYSE IMP IMPERIAL CAPITAL 11.08 10.19

BANCORP INC. NASD IFON INFOSONICS CORP. 0.68 0.74 AMEX INO INOVIO BIOMEDICAL CORP. 0.96 0.98 NASD IVGN INVITROGEN CORP. 42.83 43.94 NASD ISIS ISIS PHARMACEUTICALS INC. 18.15 18.79 NYSE JBX JACK IN THE BOX INC. 24.91 25.89 OTC JAVO.OB JAVO BEVERAGE CO. INC. 0.56 0.65 OTC JMAR.OB JMAR TECHNOLOGIES INC. 0.14 0.18 NASD KTOS KRATOS DEFENSE & SECURITY 1.99 1.85

SOLUTIONS INC. NASD WPC LAJOLLA PHARMACEUTICAL CO. 2.00 1.94 NASD LEAP LEAP WIRELESS INTERNATIONAL 40.79 42.78

INC. NASD MXWL MAXWELL TECHNOLOGIES INC. 12.22 13.07 NASD MNOV MEDICINOVA INC. 3.67 3.70 NASD MBRX METABASIS THERAPEUTICS INC. 1.55 1.43 OTC MIIS.OB MICROISLET INC. 0.25 0.30 NASD MITI MICROMET INC. 5.90 4.04 NASD NGEN NANOGEN INC. 0.33 0.39 NASD NAII NATURAL ALTERNATIVES 7.57 7.97

INTERNATIONAL INC. NASD NBIX NEUROCRINE BIOSCIENCES INC. 4.70 4.70 NASD NICH NITCHES INC. 1.04 0.81 NASD NVTL NOVATEL WIRELESS INC. 8.40 9.16 AMEX NTN NTN BUZZTIME INC. 0.32 0.32 NASD NUVA NUVASIVE INC. 50.75 56.01 NASD OPTR OPTIMER PHARMACEUTICALS INC. 8.17 9.35 NASD OREX OREXIGEN THERAPEUTICS INC. 10.37 10.42 NASD OVRL OVERLAND STORAGE INC. 0.98 1.08 NASD PACW PACWEST BANCORP. 20.41 22.70 OTC PTSC.OB PATRIOT SCIENTIFIC CORP. 0.24 0.26 AMEX PXG PHOENIX FOOTWEAR GROUP INC. 1.19 1.10 NASD PICO PICO HOLDINGS INC. 45.74 46.83 NASD PSMT PRICESMART INC. 21.53 22.83 NASD PURE PURE BIOSCIENCE 4.59 4.97 NASD QCOM QUALCOMM INC. 54.79 54.21 NASD ODEL QUIDEL CORP. 19.48 20.00 NYSE O REALTY INCOME CORP. 25.11 25.30 NYSE RMD RESMED INC. 44.20 44.45 NASD RFIL RF INDUSTRIES LTD. 7.90 7.52 NASD ROYL ROYALE ENERGY INC. 6.39 5.70 NASD BUBO RUBIO'S RESTAURANTS INC. 6.35 5.52 NYSE SAI SAIC INC. 19.19 18.90 NASD SLATS SANTARUS INC. 2.46 2.51 NYSE SRE SEMPRA ENERGY 56.77 56.66 NASD SNMX SENOMYX INC. 3.90 4.39 NASD SQNM SEQUENOMINC. 20.50 19.71 OTC SHSO.PK SOUND HEALTH SOLUTIONS 0.02 0.02 OTC TDLPOB TRANSDEL PHARMACEUTICALS 1.50 1.60

INC. NASD VSAT VIASAT INC. 26.30 27.74 NASD VICL VICAL INC. 3.29 3.51 NASD WDFC WD-40 CO. 34.89 37.44 NASD WBSN WEBSENSE INC. 22.53 22.60

NET PERCENT 52-WEEK COMPANY NAME CHANGE CHANGE HIGH 1ST PACIFIC BANCORP -0.55 -7.43% 15.50 ACADIA PHARMACEUTICALS INC. -0.2 -6.43% 16.56 ACCELRYS INC. -0.07 -1.35% 8.24 ADVENTRX PHARMACEUTICALS -0.01 -3.45% 2.70

INC. ALDILA INC. -0.2 -4.85% 18.36 ALPHATECH HOLDINGS INC. -0.06 -1.19% 6.53 AMERICAN TECHNOLOGY CORP. -0.1 -8.85% 4.19 AMN HEALTHCARE SERVICES INC. 0.43 2.43% 20.05 AMYLIN PHARMACEUTICALS INC. -4.72 -14.20% 51.10 ANADYS PHARMACEUTICALS INC. -0.38 -13.67% 3.13 ARENA PHARMACEUTICALS INC. 0.16 2.60% 14.78 ASHWORTH INC. -0.43 -12.39% 7.10 AVANIR PHARMACEUTICALS -0.04 -4.12% 2.84 AXESSTEL INC. -0.02 -2.01% 1.20 BIOMED REALTY TRUST INC. -0.98 -3.67% 27.90 CADENCE PHARMACEUTICALS INC. -0.74 -7.40% 15.70 GALLAWAY GOLF CO. -0.66 -4.61% 18.20 CARDIODYNAMICS -0.07 -5.07% 4.55

INTERNATIONAL CORP. CARDIUM THERAPEUTICS INC. -0.08 -3.90% 3.19 CHARLOTTE RUSSE HOLDING INC. -0.05 -0.40% 20.61 COHU INC. -0.96 -5.27% 20.99 CUBIC CORP. 0.35 1.21% 50.68 CYMER INC. -0.74 -2.38% 44.73 CYPRESS BIOSCIENCES INC. -0.49 -6.79% 15.60 DALRADA FINANCIAL CORP. 0.01 16.67% 0.70 DEXCOM INC. -0.2 -3.10% 10.91 DIGIRAD CORP. 0.11 6.15% 4.68 DEI HOLDINGS INC. -0.2 -11.76% 6.00 DIVX INC. 0.07 0.85% 19.35 DOT HILL SYSTEMS CORP. -0.18 -7.44% 4.12 ENCORE CAPITAL GROUP INC. -0.82 -7.01% 13.00 FIRST PACTRUST BANCORP INC. 0.10 0.88% 26.35 GENOPTIX INC. 0.02 0.06% 39.79 GEN-PROBE INC. -2.01 -3.34% 71.84 HALOZYME THERAPEUTICS -0.49 -6.42% 10.50 HOLLIS-EDEN PHARMACEUTICALS 0.00 0.00% 2.87

INC. IDM PHARMA INC. 0.35 11.86% 3.88 ILLUMINA INC. 2.20 2.43% 95.75 IMAGEWAKE SYSTEMS INC. 0.05 11.11% 2.00 IMPERIAL CAPITAL 0.89 8.73% 39.32

BANCORP INC. INFOSONICS CORP. -0.06 -8.11% 3.80 INOVIO BIOMEDICAL CORP. -0.02 -2.04% 2.09 INVITROGEN CORP. -1.11 -2.53% 49.58 ISIS PHARMACEUTICALS INC. -0.64 -3.41% 20.15 JACK IN THE BOX INC. -0.98 -3.79% 35.13 JAVO BEVERAGE CO. INC. -0.09 -13.85% 1.23 JMAR TECHNOLOGIES INC. -0.04 -22.22% 0.28 KRATOS DEFENSE & SECURITY 0.14 7.57% 3.09

SOLUTIONS INC. LAJOLLA PHARMACEUTICAL CO. 0.06 3.09% 4.71 LEAP WIRELESS INTERNATIONAL -1.99 -4.65% 85.75

INC. MAXWELL TECHNOLOGIES INC. -0.85 -6.50% 14.75 MEDICINOVA INC. -0.03 -0.81% 9.00 METABASIS THERAPEUTICS INC. 0.12 8.39% 3.33 MICROISLET INC. -0.05 -16.67% 0.74 MICROMET INC. 1.86 46.04% 6.50 NANOGEN INC. -0.06 -15.38% 1.99 NATURAL ALTERNATIVES -0.4 -5.02% 9.20

INTERNATIONAL INC. NEUROCRINE BIOSCIENCES INC. 0.00 0.00% 13.07 NITCHES INC. 0.23 28.40% 3.38 NOVATEL WIRELESS INC. -0.76 -8.30% 27.20 NTN BUZZTIME INC. 0.00 0.00% 0.98 NUVASIVE INC. -5.26 -9.40% 57.82 OPTIMER PHARMACEUTICALS INC. -1.18 -12.62% 9.70 OREXIGEN THERAPEUTICS INC. -0.05 -0.48% 18.45 OVERLAND STORAGE INC. -0.1 -9.26% 2.88 PACWEST BANCORP. -2.29 -10.09% 62.56 PATRIOT SCIENTIFIC CORP. -0.02 -7.69% 0.94 PHOENIX FOOTWEAR GROUP INC. 0.09 8.18% 3.46 PICO HOLDINGS INC. -1.09 -2.33% 47.70 PRICESMART INC. -1.3 -5.69% 33.67 PURE BIOSCIENCE -0.38 -7.65% 8.72 QUALCOMM INC. 0.58 1.07% 56.88 QUIDEL CORP. -0.52 -2.60% 21.22 REALTY INCOME CORP. -0.19 -0.75% 30.70 RESMED INC. -0.25 -0.56% 54.58 RF INDUSTRIES LTD. 0.38 5.05% 8.50 ROYALE ENERGY INC. 0.69 12.11% 14.70 RUBIO'S RESTAURANTS INC. 0.83 15.04% 11.90 SAIC INC. 0.29 1.53% 21.90 SANTARUS INC. -0.05 -1.99% 3.24 SEMPRA ENERGY 0.11 0.19% 64.21 SENOMYX INC. -0.49 -11.16% 13.99 SEQUENOMINC. 0.79 4.01% 23.00 SOUND HEALTH SOLUTIONS 0.00 0.00% 0.13 TRANSDEL PHARMACEUTICALS -0.1 -6.25% 3.50

INC. VIASAT INC. -1.44 -5.19% 36.49 VICAL INC. -0.22 -6.27% 5.23 WD-40 CO. -2.55 -6.81% 42.70 WEBSENSE INC. -0.07 -0.31% 22.93

52-WEEK SHARES MARKET ($000) COMPANY NAME LOW OUTSTANDING CAPITALIZATION 1ST PACIFIC BANCORP 5.51 4950 33907.5 ACADIA PHARMACEUTICALS INC. 2.32 37130 108048.3 ACCELRYS INC. 4.24 27080 138920.4 ADVENTRX PHARMACEUTICALS 0.23 90250 25270

INC. ALDILA INC. 3.99 5160 20227.2 ALPHATECH HOLDINGS INC. 3.32 47420 236625.8 AMERICAN TECHNOLOGY CORP. 0.95 30540 31456.2 AMN HEALTHCARE SERVICES INC. 14.25 33740 611031.4 AMYLIN PHARMACEUTICALS INC. 23.75 137240 3912712.4 ANADYS PHARMACEUTICALS INC. 1.36 28770 69048 ARENA PHARMACEUTICALS INC. 4.55 73900 467048 ASHWORTH INC. 2.47 14710 44718.4 AVANIR PHARMACEUTICALS 0.85 78200 72726 AXESSTEL INC. 0.19 23230 22765.4 BIOMED REALTY TRUST INC. 19.32 71720 1846790 CADENCE PHARMACEUTICALS INC. 4.84 38360 355213.6 GALLAWAY GOLF CO. 10.63 64800 884520 CARDIODYNAMICS 0.70 7240 9484.4

INTERNATIONAL CORP. CARDIUM THERAPEUTICS INC. 1.50 46930 92452.1 CHARLOTTE RUSSE HOLDING INC. 9.90 20870 260248.9 COHU INC. 13.27 23210 400836.7 CUBIC CORP. 20.58 26730 779446.8 CYMER INC. 22.86 29630 899566.8 CYPRESS BIOSCIENCES INC. 6.17 37880 254932.4 DALRADA FINANCIAL CORP. 0.03 5140 359.8 DEXCOM INC. 3.69 29680 185500 DIGIRAD CORP. 1.57 18930 35967 DEI HOLDINGS INC. 0.99 25510 38265 DIVX INC. 6.12 32190 267820.8 DOT HILL SYSTEMS CORP. 2.04 46060 103174.4 ENCORE CAPITAL GROUP INC. 6.10 23020 250227.4 FIRST PACTRUST BANCORP INC. 10.44 4320 49680 GENOPTIX INC. 20.41 16530 585823.2 GEN-PROBE INC. 44.82 54210 3154479.9 HALOZYME THERAPEUTICS 4.19 80390 573984.6 HOLLIS-EDEN PHARMACEUTICALS 1.40 29080 47691.2

INC. IDM PHARMA INC. 0.57 25180 83094 ILLUMINA INC. 46.00 57160 5291301.2 IMAGEWAKE SYSTEMS INC. 0.25 18080 9040 IMPERIAL CAPITAL 2.75 5430 60164.4

BANCORP INC. INFOSONICS CORP. 0.52 14910 10138.8 INOVIO BIOMEDICAL CORP. 0.50 43890 42134.4 INVITROGEN CORP. 36.73 92310 3953637.3 ISIS PHARMACEUTICALS INC. 10.91 94680 1718442 JACK IN THE BOX INC. 17.79 56710 1412646.1 JAVO BEVERAGE CO. INC. 0.42 159600 89376 JMAR TECHNOLOGIES INC. 0.04 53880 7543.2 KRATOS DEFENSE & SECURITY 1.33 104960 208870.4

SOLUTIONS INC. LAJOLLA PHARMACEUTICAL CO. 1.45 48250 96500 LEAP WIRELESS INTERNATIONAL 29.87 69210 2823075.9

INC. MAXWELL TECHNOLOGIES INC. 7.10 21140 258330.8 MEDICINOVA INC. 3.27 11960 43893.2 METABASIS THERAPEUTICS INC. 0.83 34240 53072 MICROISLET INC. 0.19 54590 13647.5 MICROMET INC. 1.22 40870 241133 NANOGEN INC. 0.27 77060 25429.8 NATURAL ALTERNATIVES 5.85 7020 53141.4

INTERNATIONAL INC. NEUROCRINE BIOSCIENCES INC. 4.00 38440 180668 NITCHES INC. 0.50 6020 6260.8 NOVATEL WIRELESS INC. 7.42 32540 273336 NTN BUZZTIME INC. 0.25 55200 17664 NUVASIVE INC. 29.59 35880 1820910 OPTIMER PHARMACEUTICALS INC. 5.85 29700 242649 OREXIGEN THERAPEUTICS INC. 6.89 34320 355898.4 OVERLAND STORAGE INC. 0.93 12760 12504.8 PACWEST BANCORP. 11.30 27200 555152 PATRIOT SCIENTIFIC CORP. 0.15 391470 93952.8 PHOENIX FOOTWEAR GROUP INC. 1.01 8170 9722.3 PICO HOLDINGS INC. 28.62 18840 861741.6 PRICESMART INC. 17.12 29690 639225.7 PURE BIOSCIENCE 2.58 29300 134487 QUALCOMM INC. 35.17 1640000 89855600 QUIDEL CORP. 13.50 32490 632905.2 REALTY INCOME CORP. 20.27 101340 2544647.4 RESMED INC. 20.51 76990 3402958 RF INDUSTRIES LTD. 5.20 3290 25991 ROYALE ENERGY INC. 2.18 8500 54315 RUBIO'S RESTAURANTS INC. 4.25 9950 63182.5 SAIC INC. 16.75 407070 7811673.3 SANTARUS INC. 1.78 51530 126763.8 SEMPRA ENERGY 48.58 246380 13986992.6 SENOMYX INC. 3.73 30590 119301 SEQUENOMINC. 4.43 56800 1164400 SOUND HEALTH SOLUTIONS 0.02 3480 69.6 TRANSDEL PHARMACEUTICALS 1.05 15550 23325

INC. VIASAT INC. 19.06 30720 807936 VICAL INC. 3.00 39490 129922.1 WD-40 CO. 26.50 16440 573591.6 WEBSENSE INC. 15.43 45050 1014976.5 Source: Trade Trends Inc. 509-327-1279