In-Gene-Ious Investing

Welcome to the new world of genomics-the study of genes. It makes up one part of the health-sciences investing universe, which typically includes biotechnology, pharmaceutical, diagnostic, managed-health-care and medical-equipment companies. And even though 1999's performance numbers for the 67 mutual funds making up Lipper's Health/Biotechnology fund category weren't the hottest around-the average fund in that category was up 17.44 percent in 1999-long-term shareholders in these types of funds have, on average, seen the value of their portfolios increase163 percent over the past five years. (Not to mention, 1,769 percent over the past 15 years.) So there's money to be made here-provided you know where to look.

Eaton Vance's Worldwide Health Sciences Fund is one of eight health/biotech funds with a 10-year track record. Since its 1985 inception, it's returned about 18 percent per year to its shareholders. That places it well ahead of the 10-year performance records of the average stock funds and S&P 500 funds. Not too shabby for a fund that holds about 40 securities and invests its assets worldwide in some of the smallest and largest drug and research companies on the planet.

"Ninety percent of the market value in pharmaceuticals is composed of 50 stocks around the world, " says Samuel D. Isaly, portfolio manager of the fund and founding principal of OrbiMed Advisors, the firm that manages the fund for Eaton Vance. "There are another 350 (companies) that make up the remaining 10 percent; they are the small biotechs."

The fund invests a portion of the portfolio in emerging companies that are still private (less than $100 million) and in companies with up to $200 billion market capitalization.

Biota was the fund's shining star last year. It's an Australian company that discovered the flu drug, Relenza. Isaly bought shares in the company in 1991 and sold them this past year after the stock had risen 50-fold. Abgenix is one of his current holdings. "It's in the business of monoclonal antibodies, which hooks into the stuff called genomics. [Genomics] is the study of your DNA, which is God's software," Isaly explains. In the fund's portfolio for three years now, the stock's price has rocketed from $6.50 to $130 per share.

While international opportunities in the biotechs abound, no one corner of the world has yet captured Islay's complete attention. At press time, for example, roughly 70 percent of the assets in the Worldwide Health Sciences Fund were invested in U.S. companies. The remaining 30 percent was invested internationally. A look back to the mid-1990s, however, reveals the situation was just the opposite. So even though the fund invests for the long-term, shareholders are likely to see portfolio holdings change as the opportunities do.

Expect some risk. Investing in small biotech and health-related companies worldwide can be dicey-lawsuits and fierce competition can destroy corporate profits. But now that we're living longer and quality of life is important, investigating the world of health sciences/biotechnology funds has become a natural next step.

Dian Vujovich is a nationally syndicated mutual fund columnist and author of 101 Mutual Fund FAQs (Chandler House Press). For free educational mutual fund information, visit her Web site, www.diansfundfreebies.com.

At A Glance

• Fund Name: Eaton Vance Worldwide Health Sciences Fund (ETHSX)
  
• Managed By: OrbiMed Advisors Inc. for Eaton Vance.
  
• Portfolio Manager: Samuel D. Isaly
  
• Total Assets: $450 million
  
• Top Holding: Abjenix, Altana AG, Fujisawa, Roach, Serono, Warner-Lambert
  
• Average Annual Return: 20.26% for Class A, 20.12% for Class B (since its inception date in 1985)
  
• Maximum Load: 5.75% (B and C shares also available)
  
• Total Expense Ratio: 1.64% for Class A shares, 2.24% for Class B shares
  
• Minimum Initial Investment: $1,000
  
• Management Fee: 1.1%
  
• Phone: (800) 225-6265
  
• Web Site: www.eatonvance.com