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Driving an unfamiliar car in an unfamiliar city isn't much fun. Though printed directions can help, many road warriors are finding GPS devices to be a better option, and are bringing their own portable systems (such as Garmin's Nüvi 750) along when they travel.
Another option is a rental car with GPS. Most major rental car companies charge $10 to $11 a day for an in-car GPS; order it when you make a reservation.